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t(11;18)(q21;q21.1): A recurring translocation in lymphomas of mucosa-associated lymphoid tissue (malt)?

✍ Scribed by Douglas Horsman; Randy Gascoyne; Robert Coupland; Richard Klasa

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 610 KB
Volume: 4
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870040213

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✦ Synopsis

A distinct subtype of extranodal malignant lymphoma derived from mucosa-associated lymphoid tissues (MALT) has recently been defined. W e have detected an acquired t( I l;l8)(q2l;q2l.l) in a patient with a MALT lymphoma of the stomach. This translocation has previously been described in two other patients with extranodal lymphoma. The BCLZ oncogene, which is located at band I8q2 I .3 and is activated by the t( 14; IB)(q32;q2 I) in follicular lymphoma, was not rearranged in this case. This newly identified t( I I; 18) may be a recurring translocation specifically associated with MALT lymphomas. Genes located at the breakpoint sites of chromosome I I and/or chromosome 18 may be crucial to the pathogenesis of this type of malignant lymphoma. Genes Chrom Cancer 4:183-187 (1992).

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