T cells: Selection and tolerance involve autophagy
β Scribed by Leavy, Olive
- Book ID
- 109955980
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 129 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1474-1741
- DOI
- 10.1038/nri2418
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The B-lymphocyte repertoire can be divided into a primary repertoire of virgin B cells and a secondary repertoire of antigenically experienced cells. Self-tolerance requires that neither of these repertoires contains potentially active cells capable of high-affinity, anti-self antibody production. R
Peripheral tolerance is induced under conditions that avoid activation of antigen-presenting cells (APCs) to release cytokines. Such tolerance occurs in both CD4+ T helper (Th)-cell subsets (Th1 and Th2), probably because it is induced in precursor cells. By contrast, activation of APCs to release c
Apoptosis is important for maintaining peripheral lymphocyte homeostasis and for minimizing the accumulation of autoreactive lymphocytes. Disruption of apoptotic pathways has been linked to lymphadenopathy, breakdown of peripheral tolerance and the development of autoimmune diseases. Major progress