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T cells: Selection and tolerance involve autophagy

✍ Scribed by Leavy, Olive


Book ID
109955980
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
129 KB
Volume
8
Category
Article
ISSN
1474-1741

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Apoptosis is important for maintaining peripheral lymphocyte homeostasis and for minimizing the accumulation of autoreactive lymphocytes. Disruption of apoptotic pathways has been linked to lymphadenopathy, breakdown of peripheral tolerance and the development of autoimmune diseases. Major progress