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T cells in a suppressor circuit and non-T: non-B cells bear different 1-J determinants

✍ Scribed by Donal B. Murphy; Katsumi Yamauchi; Sonoko Habu; Diane D. Eardley; Richard K. Gershon

Book ID
104734901
Publisher
Springer-Verlag
Year
1981
Tongue
English
Weight
548 KB
Volume
13
Category
Article
ISSN
0093-7711

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✦ Synopsis

T cells involved in the generation of suppressor activity bear an I-Jsubregion controlled determinant (e. g., J1) which is distinct from that (e. g., J2) found on non-T: non-B accessory cells. T-cell subsets examined include Ly-1 inducer and Ly-l,2 acceptor cells which collaborate to generate suppressor activity in the in vitro sheep red blood cell antibody system. Non-T:non-B accessory cells examined include accessory cells involved in concanavalin-A induced, T-cell proliferative responses and in in vitro antibody responses to sheep red blood cells. These results provide evidence for serologic and genetic complexity of the I-J subregion of the murine H-2 gene complex. * Lymph-node cells treated with anti-I k plus complement. t Peritoneal washout cells treated first with anti-Thy-1 plus complement and aliquots then treated with NMS or anti-l-J plus complement. * Mean of cpm 3(H) Tdr incorporation _+ S. D. of triplicate cultures.

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