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A non-T: Non-B cell bears I-A, I-E, I-J, and Tla (Qa-1?) determinants

✍ Scribed by Sonoko Habu; Katsumi Yamauchi; Richard K. Gershon; Donal B. Murphy

Book ID
104734902
Publisher
Springer-Verlag
Year
1981
Tongue
English
Weight
654 KB
Volume
13
Category
Article
ISSN
0093-7711

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✦ Synopsis

A non-Y:non-B accessory cell in peritoneal washout or spleen-cell suspensions facilitates T-cell proliferative responses to the mitogen, concanavalin A. Utilizing monoclonal antibody, we show that this accessory cell bears the same I-A-and I-E-subregion controlled determinants as found on B cells. In addition, the same accessory cell bears a Tla (Qa-l?)-region and an I-Jsubregion controlled determinant. This I-J determinant is also present on splenic accessory cells involved in in vitro antibody responses to sheep red blood cells. Data in a companion paper show that not all anti-I-J sera contain antibody reactive with the accessory cell, and suggest that T cells involved in the generation of suppressor activity and accessory cells bear different I-J-subregion controlled determinants.

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## Abstract Tla^d^ mice have a distinct Qed‐1 allele, Qed‐1^d^. Its product is detected by cytotoxic T cells raised in C57BW6 (H‐2^b^, Tla^b^) mice against cells from a new recombinant, B6‐TL.123^+^ (H‐2^b^, Tla^d/b^). Qed‐1^d^ is also found on cells from B10.M, A.CA and B10.STC90 mice. It cross‐re