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Polymorphism of a Qa-1-associated antigen defined by cytotoxic T cells. I. Qed-1a and Qed-1d

✍ Scribed by Kirsten Fischer Lindahl; Barbara Hausmann; Lorraine Flaherty

Publisher: John Wiley and Sons
Year: 1982
Tongue: English
Weight: 758 KB
Volume: 12
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830120211

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Tla^d^ mice have a distinct Qed‐1 allele, Qed‐1^d^. Its product is detected by cytotoxic T cells raised in C57BW6 (H‐2^b^, Tla^b^) mice against cells from a new recombinant, B6‐TL.123^+^ (H‐2^b^, Tla^d/b^). Qed‐1^d^ is also found on cells from B10.M, A.CA and B10.STC90 mice. It cross‐reacts weakly with Qed‐1^b^. (C57BL/6 X BALB/c) F~1~ anti‐B10. A (SR) effectors discriminate Qed‐1^a^ and Qed‐1^d^, while C3H/HeJ anti‐B10. BR effectors cross‐react extensively. CB6F~1~ anti‐5R effector cells also discriminate between the Qed‐1 antigens of B6‐Tla^a^ (H‐2^b^, Tla^a^) and those of B10. BR and other H‐2k, Tla^a^ strains.

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