𝔖 Bobbio Scriptorium
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T-cell tolerance

✍ Scribed by B.J. Fowlkes; Fred Ramsdell

Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
1019 KB
Volume
5
Category
Article
ISSN
0952-7915

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Despite the acceptance of principles such as clonal deletion in the thymus and peripheral clonal anergy, several new issues have arisen in the study of T-cell tolerance. For example, in the case of thymic tolerance, it is now clear that several distinct components of the thymus, including various su

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T-cell tolerance to self antigens is maintained by events that occur within the thymus and in the periphery. Mechanisms that operate on immature T cells within the thymus are effective in induction of tolerance to viruses, but mechanisms of tolerizing mature T cells are likely to break down. This fa

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## Abstract The immune system uses several mechanisms of central and peripheral tolerance in order to prevent the activation of T lymphocytes toward self‐antigens. Although the importance of immune self‐tolerance has been established for a long time, some essential cellular and molecular mechanisms