✦ LIBER ✦

T-cell tolerance to viruses

✍ Scribed by Rafi Ahmed

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 515 KB
Volume: 3
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(91)90006-m

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✦ Synopsis

T-cell tolerance to self antigens is maintained by events that occur within the thymus and in the periphery. Mechanisms that operate on immature T cells within the thymus are effective in induction of tolerance to viruses, but mechanisms of tolerizing mature T cells are likely to break down. This failure of peripheral mechanisms to induce T-cell tolerance to viruses has implications for autoimmunity and for treatment of chronic viral infections.

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