✦ LIBER ✦

T-cell selection

✍ Scribed by Stephen C Jameson; Michael J Bevan

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 557 KB
Volume: 10
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(98)80251-3

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✦ Synopsis

Major histocompatibility complex (MHC) molecules in the thymus select from the repertoire of germline receptors those that will be most useful in mounting responses to antigen in the periphery. Recent data has shed light on the involvement of self peptides presented by the MHC in this process, and has indicated that a requirement for the constant recognition of 'self' may be essential for T-cell longevity in the periphery.

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