A differential-avidity model for T-cell selection
✍ Scribed by Philip G. Ashton-Rickardt; Susumu Tonegawa
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 629 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-5699
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Activation of mature CD8^+^ T cells requires recognition, __via__ the T cell receptor (TCR), of peptide + MHC (pMHC) complexes with an avidity that exceeds a designated threshold. Multiple indicators of T cell avidity have been described that provide unique information on the characteri
## Abstract HIV‐1‐specific CD8^+^ T cells are present in most HIV‐1‐infected people and play an important role in controlling viral replication, but the characteristics of an effective HIV‐specific T‐cell response are largely unknown. The majority of HIV‐2‐infected people behave as long‐term non‐pr
During the past year significant advances have been made in our understanding of the factors contributing to the differentiation of CD4 T helper cell subsets. These have been driven, in part, by the realization that signals (cytokines) from the innate immune response are critical in T cell subset di