𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Highly avid, oligoclonal, early-differentiated antigen-specific CD8+ T cells in chronic HIV-2 infection

✍ Scribed by Aleksandra Leligdowicz; Clayton Onyango; Louis-Marie Yindom; YanChun Peng; Matthew Cotten; Assan Jaye; Andrew McMichael; Hilton Whittle; Tao Dong; Sarah Rowland-Jones

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
835 KB
Volume
40
Category
Article
ISSN
0014-2980

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

HIV‐1‐specific CD8^+^ T cells are present in most HIV‐1‐infected people and play an important role in controlling viral replication, but the characteristics of an effective HIV‐specific T‐cell response are largely unknown. The majority of HIV‐2‐infected people behave as long‐term non‐progressors while those who progress to AIDS do so in a manner indistinguishable from HIV‐1. A detailed study of HIV‐2 infection may identify protective immune responses. Robust gag p26‐specific T‐cell responses are elicited during HIV‐2 infection and correlate with control of viremia. In this study, we analyzed features of an HLA‐B^*^3501‐restricted T‐cell response to HIV‐2 p26 that may contribute to virus control. In contrast to HIV‐1, HIV‐2‐specific T cells are at an early stage of differentiation (CD27^+^CD28^+^), a finding that relates directly to CD4^+^ T‐cell levels and inversely to immune activation. The cells demonstrate IFN‐γ secretion, oligoclonal T‐cell receptor Vβ gene segment usage, exceptional avidity and secretion of pro‐inflammatory cytokines. Despite the potentially strong selection pressure imposed on the virus by these cells, there was no evidence of HIV‐2 sequence evolution. We propose that in chronic HIV‐2 infection, the maintenance of early‐differentiated, highly avid CD8^+^ T cells could account for the non‐progressive course of disease. Such responses may be desirable from an HIV vaccine.

📜 SIMILAR VOLUMES

Impact of changes in antigen level on CD
Impact of changes in antigen level on CD38/PD-1 co-expression on HIV-specific CD8 T cells in chronic, untreated HIV-1 infection
✍ Thomas Vollbrecht; Heike Brackmann; Nadja Henrich; Joerg Roeling; Ulrich Seybold 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 371 KB

## Abstract Excessive immune activation is a hallmark of chronic uncontrolled HIV infection. During the past years, growing evidence suggests that immune inhibitory signals also play an important role in progressive disease. However, the relationship between positive and negative immune signals on

Interleukin-2 reconstitutes defective hu
Interleukin-2 reconstitutes defective human immunodeficiency virus (HIV), and cytomegalovirus (CMV) specific CD8+ T cell proliferation in HIV infection
✍ Jie Yu; Huiyuan Chen; Helen Horton; Anju Bansal; Julie M. McElrath; Richard Reic 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 334 KB

## Abstract Recent studies indicate that a defective proliferative response of HIV‐specific CD8+ T cells is associated with the lack of virologic control in chronic HIV infection in humans. The possible mechanisms that might be responsible for the reduced proliferative potential of HIV‐specific CD8

Cross-linking of the T cell receptor com
Cross-linking of the T cell receptor complex with the subset-specific differentiation antigen stimulates interleukin 2 receptor expression in human CD4 and CD8 T cells
✍ Frank Emmrich; Lothar Kanz; Klaus Eichmann 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 661 KB

Nonpolymorphic interactions between the T cell differentiation antigens CD4 or CD8 and major histocompatibility complex (MHC)-encoded molecules have been postulated to participate in antigen recognition of MHC-restricted T cells. This would imply simultaneous binding of CD418 and of the T cell recep