✦ LIBER ✦

T-cell receptor isoforms and signal transduction

✍ Scribed by Shigeo Koyasu; Luciano D'Adamio; Linda K. Clayton; Ellis L. Reinherz

Publisher: Elsevier Science
Year: 1991
Tongue: English
Weight: 880 KB
Volume: 3
Category: Article
ISSN: 0952-7915
DOI: 10.1016/0952-7915(91)90073-a

No coin nor oath required. For personal study only.

✦ Synopsis

Recent cDNA and genomic cloning have identified CD3 eta as an alternatively spliced product of the same gene locus that encodes CD3 zeta. Three distinct T-cell receptor isoforms have now been identified. A current view of the signal transduction function of these isoforms in thymocytes and T cells is discussed.

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