Lipid raft domains and protein networks in T-cell receptor signal transduction

✍ Scribed by Thomas Harder

• Publisher: Elsevier Science
• Year: 2004
• Tongue: English
• Weight: 144 KB
• Volume: 16
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/j.coi.2004.03.013

✦ Synopsis

Lipid raft domains and protein networks in T-cell receptor signal transduction

Thomas Harder

Activation of the T-cell antigen receptor (TCR) is a key event in triggering the physiological responses of T lymphocytes to antigen. The earliest TCR-evoked signalling steps, such as tyrosine phosphorylations, ras activation and induction of Ca 2þ fluxes, are initiated in the T-cell plasma membrane. It has been implicated that cholesterol-and sphingolipid-rich membrane domains, termed lipid rafts, form platforms for the regulation and transduction of TCR signals at the plasma membrane; however, recent experiments have now differentiated distinct roles for lipid-raft-mediated and protein-mediated interactions in the formation of TCR signalling membrane domains.