✦ LIBER ✦

T cell antigen-receptor signal transduction

✍ Scribed by Jeroen EM van Leeuwen; Lawrence E Samelson

Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 910 KB
Volume: 11
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(99)80040-5

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✦ Synopsis

During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-Cyl -Ca2+ signalling pathways. TCR-induced cytoskeletal changes Involve signalling through SLP-76-Vav-Nck to activate effecters of the Rho-family of GTPases. Finally, glycolipidenriched microdomains play a crucial role in T cell activation.

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