Recent studies have provided insights into how the complex structure of the T-cell antigen receptor relates to its signal transduction function. Both the CD3 and zeta subunits contain functioning signaling modules that regulate the activation of tyrosine kinases and phosphorylation of cellular subst
β¦ LIBER β¦
The B-cell antigen receptor complex: structure and signal transduction
β Scribed by Christopher M. Pleiman; Daniele D'Ambrosio; John C. Cambier
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 882 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0167-5699
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The binding of antigens to the B cell antigen receptor (BCR) results in the initiation of signaling cascades and the internalization of the antigens for processing and presentation. Recent studies indicate that antigen binding destabilizes the BCR as a mechanism to down-regulate B cell responses. Tw