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T cell receptor binding kinetics and special role of Vα in T cell development and activation

✍ Scribed by Nicholas R. J. Gascoigne; S. Munir Alam; Christina M. Lin; Marielena V. McGuire; Shane Marine; Nathalie Niederberger; Stella Redpath; Bee-Cheng Sim; Paul J. Travers; Pia Yachi; M. Anna Zal; Tomasz Zal


Book ID
111639009
Publisher
Springer-Verlag
Year
2000
Tongue
English
Weight
74 KB
Volume
21
Category
Article
ISSN
0257-277X

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The role of self-peptides in influencing the development of the T-cell repertoire has been the focus of recent studies. The findings suggest that the recognition of self-peptides bound to MHC proteins in the thymus is part of the thymic self-recognition process that results in selective maturation,