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T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

โœ Scribed by Jennifer D. Stone; Adam S. Chervin; David M. Kranz

Book ID
108782489
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
439 KB
Volume
126
Category
Article
ISSN
0019-2805

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Antigens are presented to T cells as short peptides bound to MHC molecules on the surface of body cells. The binding between MHC/peptides and T cell receptors (TCRs) has a low affinity and is highly degenerate. Nevertheless, TCR-MHC/peptide recognition results in T cell activation of high specificit