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Modelling the impact of antigen kinetics on T-cell activation and response

✍ Scribed by Chao, Dennis L; Davenport, Miles P; Forrest, Stephanie; Perelson, Alan S


Book ID
108944450
Publisher
Nature Publishing Group
Year
2004
Tongue
English
Weight
460 KB
Volume
82
Category
Article
ISSN
0818-9641

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To prime immune responses, dendritic cells (DCs) need to be activated to acquire T cell stimulatory capacity. Although some stimuli trigger interleukin 12 (IL-12) production that leads to T helper cell type 1 (T H 1) polarization, others fail to do so and favor T H 2 polarization.We show that after