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Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cells

✍ Scribed by Langenkamp, Anja; Messi, Mara; Lanzavecchia, Antonio; Sallusto, Federica

Book ID
109829041
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
162 KB
Volume
1
Category
Article
ISSN
1529-2908

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Kinetics of dendritic cell activation: i
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To prime immune responses, dendritic cells (DCs) need to be activated to acquire T cell stimulatory capacity. Although some stimuli trigger interleukin 12 (IL-12) production that leads to T helper cell type 1 (T H 1) polarization, others fail to do so and favor T H 2 polarization.We show that after

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Dendritic cells are essential for Th2 differentiation of naΔ± Β¨ve CD4 + T cells in response to aeroallergens, and in recent years it has been well established that these cells play a pivotal role in the initiation phase of allergic asthma. Dendritic cells are also crucial for maintaining eosinophilic