The antigenic specificity of the majority of T lymphocytes in the peripheral blood is determined by the combination of a and p variable region chains present in the T cell receptor complex. Currently, the Vp chains are grouped into 25 families. Historically, determination of Vp usage has relied on d
T-cell prolymphocytic leukaemia: spontaneous immunophenotypical switch from CD4 to CD8 expression
โ Scribed by Eric Tse; Chi-Chiu So; Winnie W. W. Cheung; Yok-Lam Kwong
- Book ID
- 105989669
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 216 KB
- Volume
- 90
- Category
- Article
- ISSN
- 0939-5555
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We report a case of granular lymphocyte proliferative disorder accompanied with hemolytic anemia and neutropenia. Phenotypes of the cells were T cell receptor โฅโฆ + CD3 + CD4 - CD8 + CD16 + CD56 -CD57 -. Southern blot analysis of T cell receptor โค and โฅ chains demonstrated rearranged bands in both. C