Abnormal proliferation of CD4? CD8+ ??+ T cells with chromosome 6 anomaly: Role of fas ligand expression in spontaneous regression of the cells
✍ Scribed by Ichikawa, Naoaki; Kitano, Kiyoshi; Ito, Toshiro; Nakazawa, Takayuki; Shimodaira, Shigetaka; Ishida, Fumihiro; Kiyosawa, Kendo
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 369 KB
- Volume
- 60
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
We report a case of granular lymphocyte proliferative disorder accompanied with hemolytic anemia and neutropenia. Phenotypes of the cells were T cell receptor ␥␦ + CD3 + CD4 - CD8 + CD16 + CD56 -CD57 -. Southern blot analysis of T cell receptor  and ␥ chains demonstrated rearranged bands in both. Chromosomal analysis after IL-2 stimulation showed deletion of chromosome 6. Sorted ␥␦ + T cells showed an increase in Fas ligand expression compared with the levels in sorted ␣ + T cells. The expression of Fas ligand on these ␥␦ + T cells increased after IL-2 stimulation. The patient's anemia improved along with a decrease in granular lymphocyte count and disappearance of the abnormal karyotype without treatment. The expression of Fas ligand may be involved in spontaneous regression of granular lymphocyte proliferation with hemolytic anemia. Am.