New insights into the mechanisms of atlorecognition and the interactions of the TCR with the MHC molecule-peptide complex on antigen presenting cells have focused attention on developing novel biological strategies to modify the alloimmune response. Peptides derived from various regions of MHC class
T cell mediated immunosuppression
β Scribed by Donal B. Murphy
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 916 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0952-7915
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β¦ Synopsis
Suppressor T cells down-regulate the activity of other cells in the immune system, and, albeit controversial, are believed to play a role in immunological tolerance and immunoregulation. Significant progress has been made in characterizing suppressor T cells and their receptors, and in elucidating mechanisms of immunosuppression. This knowledge is important for understanding the immune system and certain disease states and for favorably manipulating immunity.
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