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T-cell markers in tumor-infiltrating lymphocytes of head and neck cancer

✍ Scribed by Dr. Carl H. Snyderman; D. S. Heo; K. Chen; Theresa L. Whiteside; Jonas T. Johnson

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 575 KB
Volume: 11
Category: Article
ISSN: 1043-3074
DOI: 10.1002/hed.2880110408

No coin nor oath required. For personal study only.

✦ Synopsis

Fresh suspensions of tumor-infiltrating lymphocytes (TIL) from 16 patients with squamous cell carcinoma of the head and neck (SCCHN) were examined for T-cell markers including CD4 (helper-inducer), CD8 (cytotoxic-suppressor), natural killer (NK) cell, and activation surface markers using monoclonal antibodies and two-color flow cytometry. Two of 8 (25%) patients with a CD4ICD8 ratio of less than 1 developed cervical lymph node metastases; none had extracapsular spread. Six of 8 (75%) patients with a CD4/CD8 ratio of greater than l developed cervical metastases; 5 of 6 (83%) exhibited extracapsular spread. An increased CD4ICD8 ratio was attributable to a decrease in CD8+ cells. A CD4ICD8 ratio of greater than 1 may be a useful prognostic indicator of the development of cervical metastases.

HEAD & NECK 11 :331-336, 1989

T h e immune system is believed to play an important role in the resistance of the host to neoplastic growth. A local immune response is sug-

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