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T cell depletion in transgenic mice carrying a mutant gene for TCR-β

✍ Scribed by Krimpenfort, Paul; Ossendorp, Ferry; Borst, Jannie; Melief, Cornelis; Berns, Anton

Book ID
109761550
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
546 KB
Volume
341
Category
Article
ISSN
0028-0836

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Several lines of transgenic mice were produced by pronuclear injection of a full-length cDNA encoding a mutant dihydrofolate reductase (DHFR, E.C. 1.5.1.3). The mutation causes altered enzyme kinetics for folate reduction as well as low affinity for methotrexate (MTX). One line of mice carrying the