T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis
✍ Scribed by Hirokazu Sawai; Yong Wook Park; James Roberson; Toshio Imai; Jörg J. Goronzy; Cornelia M. Weyand
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 321 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0004-3591
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📜 SIMILAR VOLUMES
Objective. B lymphocytes accumulate in the inflamed joints of patients with rheumatoid arthritis (RA) and are responsible for production of high amounts of (auto)-antibodies. The aim of this study was to determine the capacity of fibroblast-like synoviocytes (FLS) to contribute to the accumulation o
## Abstract ## Objective T cells deficient in CD28 expression have been implicated in the pathogenesis of rheumatoid arthritis (RA). Given that CD28‐null T cells are functionally heterogeneous, we undertook this study to screen for novel receptors on these cells. ## Methods Seventy‐two patients