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Regulation of fibronectin and metalloproteinase expression by Wnt signaling in rheumatoid arthritis synoviocytes

✍ Scribed by Malini Sen; Jack Reifert; Kevin Lauterbach; Vladimir Wolf; Jeffrey S. Rubin; Maripat Corr; Dennis A. Carson


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
379 KB
Volume
46
Category
Article
ISSN
0004-3591

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## Abstract ## Objective Osteopontin (OPN) is a proinflammatory cytokine that plays an important role in the pathogenesis of rheumatoid arthritis (RA). OPN can be cleaved by thrombin, resulting in OPN‐R and exposing the cryptic C‐terminal α4β1 and α9β1 integrin–binding motif (SVVYGLR). Thrombin‐ac