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Kappa and delta opioid receptors are expressed but down-regulated in fibroblast-like synoviocytes of patients with rheumatoid arthritis and osteoarthritis

✍ Scribed by Hua Shen; André Aeschlimann; Nataša Reisch; Renate E. Gay; Beat R. Simmen; Beat A. Michel; Steffen Gay; Haiko Sprott


Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
263 KB
Volume
52
Category
Article
ISSN
0004-3591

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## Abstract ## Objective To determine the role and expression of the cytokine/receptor pair interleukin‐21 (IL‐21)/IL‐21 receptor (IL‐21R) in rheumatoid arthritis (RA). ## Methods The expression of IL‐21R and IL‐21 was analyzed by TaqMan real‐time polymerase chain reaction (PCR) and in situ hybr