T cell co-stimulation and in vivo tolerance
β Scribed by Deborah J. Lenschow; Jeffrey A. Bluestone
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 679 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0952-7915
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Antigen-specific T cell responses have primarily been considered in terms of activation signals delivered through the TCR and the co-stimulatory molecule CD28. In the past few years, studies have demonstrated the critical importance of inhibitory signals for regulating lymphocyte activation. CD28 an
The analysis of recent data reveals that T-cell co-stimulation is a hierarchical process with elements of mutual interdependence between individual co-stimulators. The expression and function of co-stimulatory molecules is biased on various T-cell subsets and is dependent on the T-cell differentiati