✦ LIBER ✦

Co-stimulation in T cell responses

✍ Scribed by Cynthia A Chambers; James P Allison

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 829 KB
Volume: 9
Category: Article
ISSN: 0952-7915
DOI: 10.1016/s0952-7915(97)80087-8

No coin nor oath required. For personal study only.

✦ Synopsis

Antigen-specific T cell responses have primarily been considered in terms of activation signals delivered through the TCR and the co-stimulatory molecule CD28. In the past few years, studies have demonstrated the critical importance of inhibitory signals for regulating lymphocyte activation. CD28 and its homologue cytotoxic T lymphocyte antigen-4 (CTLA-4) share the same counter-receptors on antigen-presenting cells, but recent experiments have shown that CD28 and CTLA-4 have opposite effects on T cell activation. The mechanisms responsible for integrating these activation and inhibitory signals at the cellular and molecular levels are just beginning to be elucidated.

📜 SIMILAR VOLUMES

The oncogene product Vav is a crucial re

The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation

✍ Josef M. Penninger; Klaus D. Fischer; Takehiko Sasaki; Ivona Kozieradzki; Jennif 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 1 views

T-cell co-stimulation by the CD28 ligand

T-cell co-stimulation by the CD28 ligand B7 is involved in the immune response leading to rejection of a spontaneously regressive tumor

✍ Pascal Chaux; Monique S. Martin; François Martin 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 732 KB

Cell variants from experimental tumors may lose their tumorigenicity or give rise to tumors that regress after a short period of progression in immunocompetent syngeneic animals. Rejection of these tumor cells is often 1-cell-dependent. It has recently been reported that, besides the specific signal

T cell co-stimulation and in vivo tolera

T cell co-stimulation and in vivo tolerance

✍ Deborah J. Lenschow; Jeffrey A. Bluestone 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 679 KB

Emerging paradigms of T-cell co-stimulat

Emerging paradigms of T-cell co-stimulation

✍ Richard A Kroczek; Hans Werner Mages; Andreas Hutloff 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 154 KB

The analysis of recent data reveals that T-cell co-stimulation is a hierarchical process with elements of mutual interdependence between individual co-stimulators. The expression and function of co-stimulatory molecules is biased on various T-cell subsets and is dependent on the T-cell differentiati

T-cell-T-cell collaboration in allograft

T-cell-T-cell collaboration in allograft responses

✍ Ronald G. Gill 📂 Article 📅 1993 🏛 Elsevier Science 🌐 English ⚖ 667 KB

Human 4-1BB regulates CD28 co-stimulatio

Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses

✍ Young-June Kim; Seung H Kim; Patricia Mantel; Byoung S. Kwon 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB 👁 1 views