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Emerging paradigms of T-cell co-stimulation

✍ Scribed by Richard A Kroczek; Hans Werner Mages; Andreas Hutloff

Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 154 KB
Volume: 16
Category: Article
ISSN: 0952-7915
DOI: 10.1016/j.coi.2004.03.002

No coin nor oath required. For personal study only.

✦ Synopsis

The analysis of recent data reveals that T-cell co-stimulation is a hierarchical process with elements of mutual interdependence between individual co-stimulators. The expression and function of co-stimulatory molecules is biased on various T-cell subsets and is dependent on the T-cell differentiation state. The classical paradigm of T-cell co-stimulation by professional antigen-presenting cells has to incorporate the newly recognized concept of T-cell co-stimulation in the interaction with peripheral tissues, such as endothelial or epithelial cells. The two signal paradigm of T-cell co-stimulation is being replaced by a multisignal integration concept of central and peripheral co-stimulation.

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