✦ LIBER ✦

T-cell anergy and altered T-cell receptor signaling: effects on autoimmune disease

✍ Scribed by Konstantin V. Salojin; Jian Zhang; Joaquin Madrenas; Terry L. Delovitch

Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 752 KB
Volume: 19
Category: Article
ISSN: 0167-5699
DOI: 10.1016/s0167-5699(98)01326-7

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✦ Synopsis

Immunological self-tolerance can be acquired by several mechanisms, including the induction of anergy in autoreactive T cells. In this sense, anergy is predictably advantageous for the immune system. Here, Konstantin Salojin and colleagues present an alternative view that the induction of anergy in regulatory T cells may be harmful to the host and elicit autoimmune disease.

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