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T- and B-cell defects in a novel purine nucleoside phosphorylase mutation

✍ Scribed by Somech, Raz; Lev, Atar; Simon, Amos J.; Hanna, Suhair; Etzioni, Amos


Book ID
119286746
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
282 KB
Volume
130
Category
Article
ISSN
1097-6825

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Incorporation of purine nucleosides in c
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## Abstract Cultured skin fibroblasts from a patient with T‐cell immune deficiency and an absence of purine nucleoside phosphorylase activity in red cells were assayed for their capacity to metabolize inosine and guanosine. The cultured fibroblasts were lacking activity of nucleoside phosphorylase