Purine nucleoside phosphorylase, a possible histochemical marker for T-cells in man
✍ Scribed by M. Borgers; H. Verhaegen; M. De Brabander; F. Thoné; J. Van Reempts; G. Geuens
- Book ID
- 118897113
- Publisher
- Elsevier Science
- Year
- 1977
- Tongue
- English
- Weight
- 763 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0022-1759
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The effect of ischemia and reperfusion on purine nucleoside phosphorylase was studied in an isolated perfused rat liver model. This enzyme is localized primarily in the cytoplasm of the endothelial and Kupffer cells; some activity is associated with the parenchymal cells. Levels of this enzyme accur
## Abstract Cultured skin fibroblasts from a patient with T‐cell immune deficiency and an absence of purine nucleoside phosphorylase activity in red cells were assayed for their capacity to metabolize inosine and guanosine. The cultured fibroblasts were lacking activity of nucleoside phosphorylase