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Systemic hemophagocytosis masking the diagnosis of large cell non-Hodgkin lymphoma

✍ Scribed by Sandlund, J. T.; Roberts, W. M.; Pui, C.-H.; Crist, W. M.; Behm, F. G.

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 272 KB
Volume: 29
Category: Article
ISSN: 0098-1532
DOI: 10.1002/(sici)1096-911x(199709)29:3<167::aid-mpo2>3.0.co;2-b

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✦ Synopsis

An 11-year-old female presented with clinical features suggestive of malignant histiocytosis: fever, weight loss, subcutaneous nodules, pulmonary infiltrates, adenopathy, and hepatosplenomegaly. On biopsy, lymph node and bone marrow demonstrated necrosis and extensive hemophagocytosis with no definitive evidence of malignancy; the subcutaneous nodules, however, demonstrated large-cell non-Hodgkin lymphoma. This clinicopathologic picture has been reported in adults, but not in children. Although serum G-CSF, M-CSF, and TNF levels were not elevated in this child, it is possible that other cytokines induced either directly or indirectly by the subcutaneous lymphoma resulted in hemophagocytosis.

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