✦ LIBER ✦

Cell turnover parameters in small and large cell varieties of primary intestinal non-hodgkin's lymphoma

✍ Scribed by Ingrid A. M. Gisbertz; Harry C. Schouten; Fredrik J Bot; Jan-Willem Arends

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 412 KB
Volume: 83
Category: Article
ISSN: 0008-543X
DOI: 10.1002/(sici)1097-0142(19980701)83:1<158::aid-cncr21>3.0.co;2-v

No coin nor oath required. For personal study only.

✦ Synopsis

BACKGROUND.

In contrast to primary gastric lymphoma, primary intestinal lymphoma is an uncommon condition with a poorer outcome, perhaps due to differences in its pathogenesis. In this study, the authors analyzed the roles of proliferation and apoptosis in the pathogenesis of intestinal lymphoma.

METHODS.

Fifty-one cases of intestinal non-Hodgkin's lymphoma (NHL) (10 small B-cell mucosa-associated lymphoid tissue [MALT] NHLs, 12 large B-cell MALT NHLs, 18 large B-cell NHLs, 2 small T-cell NHLs, 7 large T-cell NHLs, and 2 mantle cell NHLs) were studied for the immunohistochemical expression of MIB-1 and the TUNEL assay as well as the expresssion of bcl-2 and p53, both of which are regulatory gene products involved in apoptosis.

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