Central nervous system involvement at diagnosis in a case of pediatric CD30+ anaplastic large cell lymphoma
✍ Scribed by Kaplinsky, C.; Toren, A.; Neumann, Y.; Mandel, M.; Kenet, G.; Sharon, N.; Rechavi, G.; Biniaminov, M.; Rubanov, V.; Rosenthal, E.; Rosner, E.; Mark, Z.; Amariglio, N.; Brok-Simoni, F.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 70 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
Central nervous system (CNS) involvement in like skin involvement with epidermolysis. A Ki-1/CD30 lymphoma is extremely rare, in con-lymph node biopsy was compatible with Ki-1/ trast to the frequent involvement in other types CD30 anaplastic large cell lymphoma (ALCL). of pediatric non-Hodgkin's lymphoma. No Bone marrow aspirate and biopsy demonstrated mechanism has yet been proposed to explain reactive hyperplasia. Cytogenetic analysis disthe sparing of the blood brain barrier in Ki-1/ played hyperdiploid cells with 1p(Ϫ) in most lymphoma. We present a 2-year-old boy who cells. Cerebrospinal fluid examination showed was admitted to the Department of Pediatric pleocytosis with CD30ϩ cells. Possible mecha-Hemato-Oncology due to lethargy, progressive nisms which could enable CNS involvement in breathing difficulties, massive diffuse lymphade-this unusual case are discussed. Med. Pediatr.