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Systematic Investigation of Non-Nucleoside Inhibitors of HIV-1 Reverse Transcriptase (NNRTIs)

✍ Scribed by Anton Beyer; Luckhana Lawtrakul; Supa Hannongbua; Peter Wolschann


Publisher
Springer Vienna
Year
2004
Tongue
English
Weight
291 KB
Volume
135
Category
Article
ISSN
0026-9247

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## Abstract α‐Aminoketone hydrochlorides **2aβ€”d** were synthesized by Dakin‐West reaction from __L__‐phenylalanine and __L__‐cyclohexylalanine followed by hydrolysis in acidic medium. Treatment of **2aβ€”d** with aqueous potassium thiocyanate afforded 1, 3‐imidazole‐2‐thiones **3aβ€”d** which were alky