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Synthesis of 2-Methylsulfanyl-1H-imidazoles as Novel Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs).

โœ Scribed by Yasser M. Loksha; Mahmoud A. El-Badawi; Ahmed A. El-Barbary; Erik B. Pedersen; Claus Nielsen


Publisher
John Wiley and Sons
Year
2003
Weight
137 KB
Volume
34
Category
Article
ISSN
0931-7597

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Synthesis of 2-Methylsulfanyl-1H-imidazo
โœ Yasser M. Loksha; Mahmoud A. El-Badawi; Ahmed A. El-Barbary; Erik B. Pedersen; C ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 158 KB ๐Ÿ‘ 2 views

## Abstract ฮฑโ€Aminoketone hydrochlorides **2aโ€”d** were synthesized by Dakinโ€West reaction from __L__โ€phenylalanine and __L__โ€cyclohexylalanine followed by hydrolysis in acidic medium. Treatment of **2aโ€”d** with aqueous potassium thiocyanate afforded 1, 3โ€imidazoleโ€2โ€thiones **3aโ€”d** which were alky