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System b0,+-mediated regulation of lysine transport in Caco-2 human intestinal cells

โœ Scribed by H. Satsu; H. Watanabe; S. Arai; M. Shimizu


Publisher
Springer
Year
1998
Tongue
English
Weight
391 KB
Volume
14
Category
Article
ISSN
0939-4451

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The transport of 10 amino acid ester prodrugs of levovirin (LVV) was investigated in the human intestinal Caco-2 cell line in order to overcome the poor oral bioavailability of LVV, an investigational drug for the treatment of hepatitis C infection. The prodrugs were designed to improve the permeabi