✍ Scribed by Mme H. Brocas-Neuwels; R. Promel
No coin nor oath required. For personal study only.
SYNTHGSE DE PYRIMIDINES ET DE THIAZOLO[5,4-d]PYRIMIDINES 11. ANALOGUES DE LA SUCCINOADfiNINE (*) Mme H. BROCAS-NEUWELS et R. PROMEL Two new analogs (111 and VII) of succinoadenine have been synthesized. Starting from 7-chlorothiazolo[5,4-d]pyrimidine (I), the first one has been prepared by reaction with diethyl D,L-aspartate, followed by alkaline hydrolysis. On the other hand, direct amination of 'I-methylthiothiazol0[5.4-d]pyrimidine (IV) with D,L-aspartic acid has given a product formulated as 5-formamido-4-mercapto-6methylthiopyrimidine (V). An authentic specimen has been prepared for comparison by formy lation of 5-amino-4-chloro-6-methylthiopyrimidine (VIII) and replacement of the chlorine atom with sodium hydrosulfide. The second analog has been obtained either by reaction of 7-chlorothiazolo[5,4-d] pyrimidine (1) with D,L-mercaptosuccinic acid or by alkylation of 7-mercaptothiazolo[5,4-d]pyrimidine (VI) with D,L-bromosuccinic acid.
📜 SIMILAR VOLUMES
## Abstract 4‐Hydroxy‐6‐mercaptopyrimidines substituted in position 2 by amino‐, methyl‐ or phenyl‐groups are obtained in good yields by “the Principal Synthesis”, using a dithioester as the three‐carbon fragment. The reactions are carried out in dioxane. In ethanol containing sodium ethoxide, the
## Abstract Several new 5‐aryl‐2,3,4,5‐tetrahydrobenzo[f]1,4‐oxazepine derivatives (1 to 18) were prepared by reduction of the 2,3‐dihydro compounds. Adams platinium was a suitable catalyst for hydrogenation. With other catalysts, reduction of a nitro group or debenzylation may occur before the alt