Synthèse de Pyrimidines. Étude de la Condensation de L'éthoxycarbonyl-Dithioacetate de Méthyle Avec Les Amidines. II

✍ Scribed by M. Snyers; M. Donnez; D. Isbecque; T. Lakhanisky; R. Promel

• Publisher: Wiley (John Wiley & Sons)
• Year: 2010
• Weight: 381 KB
• Volume: 82
• Category: Article
• ISSN: 0037-9646
• DOI: 10.1002/bscb.19730820504

✦ Synopsis

Abstract

4‐Hydroxy‐6‐mercaptopyrimidines substituted in position 2 by amino‐, methyl‐ or phenyl‐groups are obtained in good yields by “the Principal Synthesis”, using a dithioester as the three‐carbon fragment. The reactions are carried out in dioxane. In ethanol containing sodium ethoxide, the 4‐hydroxy‐6‐mercaptopy‐rimidines are produced in low yields along with small amounts of the corresponding 4‐ethoxy‐6‐hydroxypyrimidines. The mass spectra of the pyrimidine derivatives have been recorded. Their major fragmentations are considered.