Synthetic study of yonarolide: stereosel
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Yohei Ueda; Hideki Abe; Kazuo Iguchi; Hisanaka Ito
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Article
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2011
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Elsevier Science
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French
โ 611 KB
Stereoselective construction of the tricyclic core of yonarolide (1), a marine norditerpenoid, was achieved. This synthetic route includes a Diels-Alder reaction and an intramolecular aldol condensation. It also involves efficient epimerization through a retro-Michael reaction-Michael addition and w