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Synthetic studies towards phorboxazole A. A concise stereoselective synthesis of the C20C26 pentasubstituted oxane ring unit

✍ Scribed by Tao Ye; Gerald Pattenden


Book ID
108386386
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
168 KB
Volume
39
Category
Article
ISSN
0040-4039

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Synthetic studies toward phorboxazole A.
✍ David R Williams; Michael P Clark; Martin A Berliner 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 250 KB

A stereocontrolled synthesis of two fragments comprising the macrocyclic core of Phorboxazole A is described. The C3-C19 bis-pyran segment is prepared utilizing reiterative enantioselective allylations from homochiral aUylstannanes followed by stereoselective cyclizations. The pentasubstituted tetra

Synthetic studies towards phorboxazole A
✍ Gerald Pattenden; Alleyn T Plowright; James A Tornos; Tao Ye 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 230 KB

A convergent and stereoselective synthesis of the C31-C46 side chain unit in the marine natural product phorboxazole A, which accommodates five asymmetric centres, three carbon-to-carbon double bonds and an oxane-hemiacetal unit, is described.