Synthetic Studies toward Phorboxazole A. Stereoselective Synthesis of the C 28 −C 46 Side Chain Fragment
✍ Scribed by Williams, David R.; Clark, Michael P.; Emde, Ulrich; Berliner, Martin A.
- Book ID
- 127029119
- Publisher
- American Chemical Society
- Year
- 2000
- Tongue
- English
- Weight
- 69 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1523-7060
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📜 SIMILAR VOLUMES
A convergent and stereoselective synthesis of the C31-C46 side chain unit in the marine natural product phorboxazole A, which accommodates five asymmetric centres, three carbon-to-carbon double bonds and an oxane-hemiacetal unit, is described.
A stereocontrolled synthesis of two fragments comprising the macrocyclic core of Phorboxazole A is described. The C3-C19 bis-pyran segment is prepared utilizing reiterative enantioselective allylations from homochiral aUylstannanes followed by stereoselective cyclizations. The pentasubstituted tetra