Synthetic studies towards (−)-carba-3′-deoxy-3′-fluorothymidine.
✍ Scribed by J. Béres; Gy. Sági; E. Baitz-Gács; I. Tömösközi; L. Gruber; L. Ötvös
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 492 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0040-4020
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## Abstract The 5‐OH‐protected methyl glycosides 2 and 3 were epimerized to give the corresponding epimers 6 and 7 via an oxidation‐reduction procedure. Reaction of 6 with diethylamino‐sulfur trifluoride (DAST) afforded the fluoro sugar 8, which was coupled with thymine to give 3′‐deoxy‐3′‐fluoroth
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