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A short route to 3′-deoxy-3′-fluorothymidine

✍ Scribed by Motawia, Mohammed S. ;Pedersen, Erik B.

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
336 KB
Volume
1990
Category
Article
ISSN
0947-3440

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✦ Synopsis

Abstract

The 5‐OH‐protected methyl glycosides 2 and 3 were epimerized to give the corresponding epimers 6 and 7 via an oxidation‐reduction procedure. Reaction of 6 with diethylamino‐sulfur trifluoride (DAST) afforded the fluoro sugar 8, which was coupled with thymine to give 3′‐deoxy‐3′‐fluorothymidine (12) after deprotection with saturated ammonia in methanol.

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Preparation of 3′-deoxy-3′-[18F]fluoroth
Preparation of 3′-deoxy-3′-[18F]fluorothymidine ([18F]FLT) in ionic liquid, [bmim][OTf]
✍ Byung Seok Moon; Kyo Chul Lee; Gwang Il An; Dae Yoon Chi; Seung Dae Yang; Chang 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 128 KB

## Abstract Although 3′‐deoxy‐3′‐[^18^F]fluorothymidine ([^18^F]FLT) is a prospective radiopharmaceutical for the imaging of proliferating tumor cell, it is difficult to prepare large amount of [^18^F]FLT. We herein describe the preparation of [^18^F]FLT in an ionic liquid, [bmim][OTf] (1‐butyl‐3‐m