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Synthetic studies on tetrodotoxin and related compounds. V. The protecting group of the C9-hydroxy group

✍ Scribed by Hideo Tanino; Shoji Inoue; Matsuhiko Aratani; Yoshito Kishi

Publisher
Elsevier Science
Year
1974
Tongue
French
Weight
175 KB
Volume
15
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES

Synthetic studies on Ξ²-lactam antibiotic
Synthetic studies on Ξ²-lactam antibiotics. VII. Mild removal of the benzyl ester protecting group with aluminum trichloride
✍ Teruji Tsuji; Takahiro Kataoka; Mitsuru Yoshioka; Yuji Sendo; Yasuhiro Nishitani πŸ“‚ Article πŸ“… 1979 πŸ› Elsevier Science 🌐 French βš– 199 KB

The benzyl ester protecting group in fi-lactam derivatives can be cleanly removed by treatment with aluminum trichloride under mild conditions, preferably in the presence of anisole, to give the corresponding free acids in high yields. The benzyl ester has been widely used as a carboxyl protecting