✦ LIBER ✦
Synthetic studies on β-lactam antibiotics. VII. Mild removal of the benzyl ester protecting group with aluminum trichloride
✍ Scribed by Teruji Tsuji; Takahiro Kataoka; Mitsuru Yoshioka; Yuji Sendo; Yasuhiro Nishitani; Shoichi Hirai; Takashi Maeda; Wataru Nagata
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 199 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The benzyl ester protecting group in fi-lactam derivatives can be cleanly removed by treatment with aluminum trichloride under mild conditions, preferably in the presence of anisole, to give the corresponding free acids in high yields.
The benzyl ester has been widely used as a carboxyl protecting group in organic syntheses.