Synthetic studies on taxol. Assembly of the bicyclo[5.3.1]undecane moiety (AB ring system) of taxane diterpenes
โ Scribed by Oh, Jonghoon; Choi, Jong Ryoo; Cha, Jin Kun
- Book ID
- 126305761
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 584 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
Bicyclo[5.3.l]undecenone 2 corresponding to A and B rings in taxane diterpenes was synthesized. The eight-membered ring was constructed by a baseinduced intramolecular cyclization of twelve-membered lactam sulfoxides 15. 204 lja,b ya,bl,b2 isomer NC-S J K \*H,6 5 4 9 07 / 11' 1 3 10 -. 2 0 H R NHMe
The Cyclopropylalkylidenecyclopropane Thermal Double Ring Expansion. A Novel Route to the Bicyclo[5.3.1]undecane Skeleton of the AB Ring System of Taxanes. -The mechanism of the reaction is explained by the initial formation of a diradical followed by opening to a homoallylic biradical which closes