Synthetic Studies on Prostanoids II Stereospecific Total Synthesis of Prostaglandin F1α
✍ Scribed by Koichi Kojima; Kiyoshi Sakai
- Publisher
- Elsevier Science
- Year
- 1972
- Tongue
- French
- Weight
- 180 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
reoeived in UK for publication 7 Juu 1972) In a preceding paper we described the stereoselective total synthesis of PGFla via the key intermediate (IV). In this communication, we wish to report the configuration of hydroxyester (IV)2, which was stereospecifically derived by Pd-C reduction (II), este
The total synthesis of the naturally occurring prostaglandin F2a (PGF2a) was achieved on a soluble non-cross-linked polystyrene support (NCPS). The approach was predicated upon a three component coupling scheme that is both synthetically flexible and convergent in nature. The methodology detailed sh