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Synthetic Studies on Prostanoids. III. Stereochemistry of the Key Intermediate (IV) in the Total Synthesis of Prostaglandin F1α

✍ Scribed by Koichi Kojima; Kiyoshi Sakai

Publisher: Elsevier Science
Year: 1972
Tongue: French
Weight: 195 KB
Volume: 13
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)94037-7

No coin nor oath required. For personal study only.

✦ Synopsis

reoeived in UK for publication 7 Juu 1972) In a preceding paper we described the stereoselective total synthesis of PGFla via the key intermediate (IV). In this communication, we wish to report the configuration of hydroxyester (IV)2, which was stereospecifically derived by Pd-C reduction (II), esterification with CH2N2 (III)4 and NaBHa reduction from the starting material (I).

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